Total sRANKL (human) ELISA

The total sRANKL (human) ELISA kit is intended for the quantitative determination of of total sRANKL (human) in serum and plasma, i.e. free sRANKL as well as sRANKL bound to OPG. 

Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) is a transmembrane protein produced by osteocytes and is part of the tumor necrosis factor (TNF) family. It is the main stimulant for osteoclast formation and is essential for their survival.

RANKL expression leads to bone reabsorption and loss which is counteracted by osteoprotegerin (OPG). RANKL/OPG regulate bone remodeling and an imbalance may lead to bone metabolic diseases.