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The Zonulin ELISA kit is intended for the quantitative determination of zonulin family peptides (ZFP) in stool. 

Zonulin is a human protein which regulates tight junctions of the digestive tract. Zonulin binds to a specific receptor on the surface of intestinal epithelia and triggers a cascade of biochemical events which induces tight junction disassembly and a subsequent permeability increase of the intestinal epithelia, allowing some substances to pass through and activate immune reactions.

The zonulin system is more activated in celiac disease and type 1 diabetes mellitus patients. 

An increased intestinal permeability, also colloquially called ‘leaky gut’, is nowadays associated with the metabolic syndrome, obesity, and several autoimmune, inflammatory, and neoplastic diseases.

The Zonulin ELISA kit is intended for the quantitative determination of zonulin family peptides (ZFP) in serum. 

Zonulin is a human protein which regulates tight junctions of the digestive tract. Zonulin binds to a specific receptor on the surface of intestinal epithelia and triggers a cascade of biochemical events which induces tight junction disassembly and a subsequent permeability increase of the intestinal epithelia, allowing some substances to pass through and activate immune reactions.

The zonulin system is more activated in celiac disease and type 1 diabetes mellitus patients. 

An increased intestinal permeability, also colloquially called ‘leaky gut’, is nowadays associated with the metabolic syndrome, obesity, and several autoimmune, inflammatory, and neoplastic diseases.

The Retinol-binding protein RBP/RBP4 ELISA kit is an enzyme immunoassay intended for the quantitative determination of free retinol-binding protein RBP/RBP4 as well as RBP4 complexed with transthyretin in plasma, serum and urine. 

Retinol-binding protein RBP/RBP4 is a transport protein for vitamin A which forms a complex with prealbumin in blood, but loses its affinity for prealbumin once the vitamin has been delivered to the target cells. The free RBP/RBP4 molecule is rapidly filtered at the glomerulus and catabolised in the renal tubules after resorption by the proximal tubular cells. In kidney disease with prevailing tubular changes, these proteins are not reabsorbed and appear in the urine. 

The elevation of serum RBP/RBP4 causes systemic insulin resistance, whereas its reduction improves the insulin action.

The Retinol-binding protein RBP/RBP4 ELISA kit is an enzyme immunoassay intended for the quantitative determination of free retinol-binding protein RBP/RBP4 as well as RBP4 complexed with transthyretin in plasma, serum and urine. 

Retinol-binding protein RBP/RBP4 is a transport protein for vitamin A which forms a complex with prealbumin in blood, but loses its affinity for prealbumin once the vitamin has been delivered to the target cells. The free RBP/RBP4 molecule is rapidly filtered at the glomerulus and catabolised in the renal tubules after resorption by the proximal tubular cells. In kidney disease with prevailing tubular changes, these proteins are not reabsorbed and appear in the urine. 

The elevation of serum RBP/RBP4 causes systemic insulin resistance, whereas its reduction improves the insulin action.

The Carbonyl protein ELISA kit is an enzyme immunoassay intended for the quantitative determination of protein carbonyls in human serum and plasma. 

Indications:

•Atherosclerosis;

•Alzheimer’s disease;

•Parkinson’s disease;

•Rheumatoid arthritis;

•Uremia;

•Diabetes;

•Ageing;

•Cancerogenesis.

The IDO activity ELISA kit is designed to determine the determination of L-kinurenin and L-tryptophan in human serum and plasma and dried blood spots.

Indoleamine 2,3-dioxygenase catalyses the degradation of L-tryptophan (TRP) to L-kynurenine (KYN) and is the ratelimiting enzyme in this pathway.

IDO activity is an important regulator of the innate and adaptive immune system. It plays an important role in finetuning of the immune system, e. g. during the development and proliferation of cancer. 

The S100A12 ELISA ELISA Kit is an enzyme immunoassay intended for the quantitative determination of S100A12 in stool.

Alternative names: Calgranulin C, EN-RAGE

Indications:

• Marker for acute inflammation;

• Estimation of gastrointestinal inflammation degree;

• Parameter for monitoring Crohn‘s disease and Colitis ulcerosa.

The Calprotectin ELISA kit is an enzyme immunoassay intended for the quantitative determination of calprotectin (MRP (8/14, S100A8/A9) in serum and plasma.

Alternative names of calprotectin: MRP8/14, L1, (p8,14), p34, S100 A8/A9

Indications:

• Concentrations of MRP8/14 in serum, and particularly in synovial fluid, correlate strongly with disease activity in rheumatoid arthritis.

• Plasma MRP8/14 levels are very early, specific and sensitive prediction markers for acute rejection in kidney allograft transplantation.

• Serum MRP8/14 concentration is a prognostic marker of recurrent infection and survival in alcoholic liver cirrhosis.

• MRP8/14 is useful for evaluating the extent of periodontal inflammation.

• In cerebral malaria, MRP 8/14 expression correlates with microglial activation in brain.

• MRP8/14 is present in urinary stones and in dental calculus.

• S100A9 in serum may serve as a useful marker for discrimination between prostate cancer and benign prostatic hyperplasia (BPH).

The Calprotectin ELISA kit is an enzyme immunoassay intended for the quantitative determination of calprotectin (MRP (8/14, S100A8/A9) in urine. 

Calprotectin is a calcium-binding protein secreted predominantly by neutrophils and monocytes.

Indications:

• Detection of urothelial (transitional cell) carcinoma of the bladder.

Exclusion criteria:

• Acute kidney injury, renal transplantation, urinary tract infection, pyuria, previous BCG treatment, secondary transurethral resection of the bladder tumor.

The Calprotectin ELISA kit is an enzyme immunoassay intended for the quantitative determination of calprotectin (MRP (8/14, S100A8/A9) in stool. 

Calprotectin is a calcium-binding protein secreted predominantly by neutrophils and monocytes.

Indications:

• Marker for acute inflammation;

• Estimation of gastrointestinal inflammation degree;

• Parameter for monitoring Crohn’s Disease, Colitis ulcerosa or the patient‘s status after removal of polyps.

The Lysozyme ELISA kit is an enzyme immunoassay intended for the quantitative determination of lysozyme in stool. 

Indications:

• Diagnosis and monitoring of Crohn’s Disease;

• Early diagnosis of rejection reactions in kidney transplantation cases;

• Differential diagnosis and monitoring of leukosis;

• Diagnosis and treatment monitoring of urinary tract infections in children;

• Differential diagnosis between viral and bacterial meningitis in children;

• Identification of sepsis in neonates.

The Lysozyme ELISA kit is an enzyme immunoassay intended for the quantitative determination of lysozyme in human serum, urine and liquor. 

Indications:

• Diagnosis and monitoring of Crohn’s Disease;

• Early diagnosis of rejection reactions in kidney transplantation cases;

• Differential diagnosis and monitoring of leukosis;

• Diagnosis and treatment monitoring of urinary tract infections in children;

• Differential diagnosis between viral and bacterial meningitis in children;

• Identification of sepsis in neonates.

The Lysozyme ELISA kit is an enzyme immunoassay intended for the quantitative determination of lysozyme in human serum, urine and liquor. 

Indications:

• Diagnosis and monitoring of Crohn’s Disease;

• Early diagnosis of rejection reactions in kidney transplantation cases;

• Differential diagnosis and monitoring of leukosis;

• Diagnosis and treatment monitoring of urinary tract infections in children;

• Differential diagnosis between viral and bacterial meningitis in children;

• Identification of sepsis in neonates.

The Lysozyme ELISA kit is an enzyme immunoassay intended for the quantitative determination of lysozyme in stool. 

Indications:

• Diagnosis and monitoring of Crohn’s Disease;

• Early diagnosis of rejection reactions in kidney transplantation cases;

• Differential diagnosis and monitoring of leukosis;

• Diagnosis and treatment monitoring of urinary tract infections in children;

• Differential diagnosis between viral and bacterial meningitis in children;

• Identification of sepsis in neonates.